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SolventSelector

Is Water miscible with Acetonitrile?

Compiled by Hemant RawatLast reviewed July 2026How we verify

Miscible

Yes — Water and Acetonitrile are miscible. They mix in all proportions to form a single, uniform phase at room temperature.

Why

Both sit close enough on the polarity scale — Water at P′ 10.2 (water) and Acetonitrile at P′ 5.8 (polar aprotic) — to mix freely. Most organic solvents are mutually miscible; water only joins in when the other solvent is polar enough to hydrogen-bond with it.

What it means for your method

You can combine these freely in a mobile phase or workup without phase separation — still confirm at your working proportions if it's critical.

Check any other pair on the interactive miscibility chart, or see full properties for Water and Acetonitrile.

General guidance for method development — miscibility varies with temperature, water content and proportions. Confirm critical mixtures at your working conditions. See ourmethodology.